對於開發者和喜愛刷機的朋友來説，Transformer Prime 的一大缺點必然是 ASUS 鎖上其 Bootloader，導致開發者無法開發該平板的 Custom Rom，超頻亦變得困難。當然，世上沒有免費午餐，要解鎖 Transformer Prime 的 Bootloader 就必須放棄其原廠保養，任何人為或非認爲的破壞都要由自己一一承擔。
ASUS 宣佈正式解封 Transformer Prime 的 Bootloader 的新聞稿：
“Once you activate the [unlock app] you will not be able to recover your ASUS product (“Original Product”) back to original locked conditions;the Original Product with the activated App will not be deemed the Original Product; the Revised Product will no longer be covered under the warranty of the Original Product; the software of Revised Product will no longer be deemed the software of the Original Product and can no longer receive ASUS software updates; your purchased digital content may also be affected.
You also acknowledge ASUS does not guarantee service satisfaction to any Revised Product, including events involving paid service requested by you to be performed to the Revised Product.
Furthermore, such repaired Revised Product will not be covered under the warranty of the Original Product; the software of the repaired Revised Product will not be deemed the software of the Original Product and will not receive ASUS software updates.
It is strongly advised that you avoid activating this App unless you fully understand and accept the risks that may arise.”
